Investigation of the potential covid-19 inhibitor from Cassia alata and Dendrophthoe petandra using computational approach

Abstract COVID-19 is a recent coronavirus outbreak caused by SARS-CoV-2 beginning in early December 2019 Wuhan China raising global health problems. The SARS main peptidase (SARS-CoV M(pro)) plays an essential role the life-cycle of virus and primary target for development anti-SARS agents. Also, viral 3-chymotrypsin-like cysteine protease 3 (3CLpro) enzyme controls replication its life cycle. Therefore, herein, we performed silico virtual screening compounds from Cassia alata Dendrophthoe petandra such as; aloe-emodin, emodin, kaempferol, quercetin quercitrin against M pro also 3CL through molecular docking approach using Autodock 4.2, with Lamarckian Genetic Algorithm. binding energies obtained result quercetin, kaempferol aloe-emodin appeared to have best potential act as inhibitors.